Antisense rna virus replication

This may not be the complete list of references from this article. National Center for Biotechnology Information , U. Journal List J Virol v.

J Virol. Author information Copyright and License information Disclaimer. Orsola, Bologna, Italy. Copyright notice. This article has been cited by other articles in PMC. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region.

Antimicrob Agents Chemother. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Inhibition of human cytomegalovirus major immediate early gene expression by antisense RNA expression vectors. J Gen Virol. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD Curr Top Microbiol Immunol. Antiviral Res. Use of recombinant virus to assess human cytomegalovirus early and late promoters in the context of the viral genome.

Site specificity of the inhibitory effects of oligo nucleoside methylphosphonate s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Human cytomegalovirus structural components: intracellular and intraviral localization of p28 and p by immunoelectron microscopy. Virus Res. Cloning and characterization of major antigenic determinants of human cytomegalovirus Ad seen by the human immune system. Arch Virol. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements.

Monoclonal antibody E M to human cytomegalovirus recognizes an epitope encoded by exon 2 of the major immediate early gene. Properties of a human cytomegalovirus-induced protein kinase. Improved retroviral vectors for gene transfer and expression. Nuclear expression of the lower matrix protein of human cytomegalovirus in peripheral blood leukocytes of immunocompromised viraemic patients. Cytomegalovirus-mediated induction of antisense mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: identification of an essential gene.

Primary structure and transcription of the genes coding for the two virion phosphoproteins pp65 and pp71 of human cytomegalovirus. Co-suppression of Dictyostelium discoideum myosin II heavy-chain gene expression by a sense orientation transcript. Antisense Res Dev. Nuclear targeting of the tegument protein pp65 UL83 of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport.

This contradiction is discussed in light of the fact that the 4-kb mRNA, which codes for pp65 and was targeted in ULantisense cell lines, may be a bicistronic mRNA which also codes for pp71 UL Thus, interference of expression from the genes encoding pp65 and pp71 by blocking of this putative bicistronic message leads to severe impairment of viral replication.

Abstract The human cytomegalovirus HCMV open reading frame UL83 encodes a phosphoprotein of 64 to 68kDa pp65 which is a major constituent of this virion and dense bodies. Publication types Research Support, Non-U.

It's sort of a new way of gene regulation that's recently been developed. Shawn Burgess, Ph. Featured Content.